Morant Bay Courthouse to be Restored Soon

first_imgMinister of Justice, Hon. Delroy Chuck, says the Morant Bay Courthouse in St. Thomas will be restored shortly.Speaking at a seminar for justices of the peace (JPs) on June 7 at the Morant Villas in Morant Bay, the Minister said the building, which was destroyed by fire more than a decade ago, will be a showpiece to lift the parish.“We want to put it together, and make it what it is supposed to be – a nice courthouse and a Justice Centre, and also a facility of which St. Thomas can be proud,” the Minister said.He underscored that with the statue of National Hero, the Rt. Excellent Paul Bogle, located in front of the building, the facility must be given credence.“We must put it together, and during the course of this fiscal year, we are going to let this courthouse come alive again,” the Minister added.For her part, Custos of the parish, Hon. Marcia Bennett, called on the JPs to use their office to “change the lives of children”, and for the promotion of “family values”.Meanwhile, Head of the European Union (EU) Delegation in Jamaica, Ambassador Malgorzata Wasilewska, said the JPs need to remain the “eyes and ears” of communities, so that the abused and those who feel that wrongs are committed against them can always turn to someone.“You have to see what happens in your community, and reach out to people, if you want to provide that link with the system and more justice for your community,” the Ambassador said.Justice centres offer several Alternative Dispute Resolution (ARD) services under one umbrella at the parish level. They accept and coordinate court referrals, using ADR mechanisms such as Restorative Justice and Child Diversion.In addition, communities, schools and other entities may utilise the services at the centres.The primary objectives of the centres include expansion of the justice system’s capacity for quasi-judicial proceedings, to reduce the cost of accessing justice to Jamaicans; reduction of case backlog; and to improve the system to meet the demands of the public.last_img read more

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October 7 2015The part of the fence between the c

first_imgOctober 7, 2015The part of the fence between the construction yard and the recycling area has been covered with new wire fence material.[photo by Hildi Cruz]Here is workshop participant Felipe tying the fencing to posts.[photo by Hildi Cruz]Felipe and Ron Chandler.[photo by Hildi Cruz]Fence posts have been set in concrete around the construction yard.[photo by Sue Kirsch]More to come.last_img

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Paternal exercise has significant impact on childs lifelong metabolic health

first_img Source:https://www.joslin.org/ Reviewed by Alina Shrourou, B.Sc. (Editor)Oct 22 2018Recent studies have linked development of type 2 diabetes and impaired metabolic health individuals to their parents’ poor diet, and there is increasing evidence that fathers play an important role in obesity and metabolic programming of their offspring.In a new study published today in the journal Diabetes, researchers at Joslin Diabetes Center have shown that paternal exercise has a significant impact on the metabolic health of their offspring well into adulthood.The study was led by Laurie Goodyear, PhD, senior investigator and head of the Section on Integrative Physiology and Metabolism at Joslin and professor of medicine at Harvard Medical School. The study was co-led by Kristin Stanford, PhD, a physiology and cell biology researcher who is now with The Ohio State University College of Medicine at the Wexner Medical Center.Related StoriesSupervised fun, exercise both improve psychosocial health of children with obesityRegular physical activity can be effective in reducing pain from arthritisResearchers identify molecular pathway underpinning exercise and improved motor learningGoodyear and Stanford investigated how a father’s exercise regimen would affect his offspring’s metabolic health. Using a mouse model, they fed male mice either a normal diet or a high-fat diet for three weeks. Some mice from each diet group were sedentary and some exercised freely. After three weeks, the mice bred and their offspring ate a normal diet under sedentary conditions for a year.The researchers report that adult offspring from sires who exercised had improved glucose metabolism, decreased body weight and a decreased fat mass.”It really shows how important it is for men to exercise prior to conceiving because it will have lifelong effects on the health of their offspring. When we put the males on a high-fat diet, it had a terrible effect on the offspring; but what was surprising was that situation was completely reversed when the male added in exercise. So translated to humans, even if dad isn’t eating really well, he can still affect his offspring positively by exercising,” said Goodyear. “This also will dramatically decrease the risk of developing type 2 diabetes for the offspring,” added Goodyear.The team also found that exercise caused changes in the genetic expression of the father’s sperm that suppress poor dietary effects and transfer to the offspring.”We saw a strong change in their small-RNA profile. Now we want to see exactly which small-RNAs are responsible for these metabolic improvements, where it’s happening in the offspring and why,” Stanford said.The researchers believe the results support the hypothesis that small RNAs in sperm could help transmit paternal environmental information to the next generation.last_img read more

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New protein target for deadly ovarian cancer

first_imgThe good news about the newly discovered protein is that it can be inhibited, thus inactivating cell processes within ovarian cancer cells to switch them from a constitutively proliferative cell cycle to one which results in senescence, or going to sleep. The key role of the protein was identified on cell culture experiments by researchers at Penn State College of Medicine.The current study focused on teasing out the differences in the metabolism of ovarian cancer cells by comparing them with cells from a normal fallopian tube.The route used to achieve this was quantitative spectrometry, which helped analyze the metabolites produced by various cellular pathways in the two type of tissue. Among the differences, it was revealed that cancer cells utilized glucose, a form of sugar, via the key energy cycle called the citric acid cycle, far more often, as against the more common use of an oxygen-requiring pathway called aerobic glycolysis. This accounts for the presence of a high level of citric acid activity in all high-grade serous ovarian cancer cells.  Related StoriesLiving with advanced breast cancerUsing machine learning algorithm to accurately diagnose breast cancerMother calls for protein shake regulation after daughter diesThis means that many therapies which inhibit the breakdown of glucose (glycolysis) to destroy cancer cells may be quite ineffective. Dahl commented that this could often result, in fact, in the production of toxins that harm normal healthy tissue.Instead, the team in the current study looked at the effects of inhibiting the wildtype or normal form of an enzyme, isocitrate dehydrogenase 1 (IDH 1), which plays a vital part in the citric acid cycle. They selected this protein because it was the only one in this pathway that is expressed at higher levels in both adherent and spheroid tumor cells. Increased activity of this enzyme severely impacts progression-free survival, which is an important outcome measured in assessing the effectiveness of any cancer therapy.Mutants of this protein are common in other tumors, but the wildtype form is typically present in cells within HGSC. The researchers hypothesize that the presence of this enzyme is an important advantage to these cells, and its inhibition is a key step to inducing senescence.The researchers found that suppressing the work of this protein stopped cell division completely by suppressing the activity of multiple other genes, inhibiting vital metabolic pathways. Both adherent cells of the primary tumor, and spheroid cells of secondary HGSC, become senescent when the wildtype IDH 1 enzyme is inhibited. Thus, this could be an excellent way to treat HGSC at all stages. This is an important consideration, as ovarian cancers are rarely diagnosed at early stages.While there are already FDA (US Food and Drug Administration)-approved drugs against one of the mutant forms of this enzyme, the team wondered whether they would work against the wildtype form as well. They found that one did, and this is now a part of their continued research agenda.Aird says, “One of our long-term goals is to try and repurpose this already-approved drug as a treatment for this form of ovarian cancer.” Besides adapting existing drugs against the enzyme to fight this type of cancer, the researchers want to examine the differences in the metabolic functioning of normal and HGSC cells more closely. Another goal is to examine the effectiveness of combining IDH 1 inhibitors with other treatments. Journal reference:Targeting IDH1 as a Prosenescent Therapy in High-grade Serous Ovarian Cancer, Erika S. Dahl, Raquel Buj, Kelly E. Leon, Jordan M. Newell, Yuka Imamura, Benjamin G. Bitler, Nathaniel W. Snyder and Katherine M. Aird, Mol Cancer Res June 17 2019 DOI: 10.1158/1541-7786.MCR-18-1233, http://mcr.aacrjournals.org/content/early/2019/06/17/1541-7786.MCR-18-1233 By Dr. Liji Thomas, MDJul 14 2019A new study shows that targeting a specific protein found within quickly spreading high-grade serous carcinomas (HGSC) of the ovary could help contain these cancers. HGSC is the most common and deadly form of epithelial ovarian cancer, which is itself the deadliest cancer of the female reproductive tract. When HGSC spreads outside the ovaries, within the peritoneal cavity, it forms detached balls called spheroids, which may look and act differently from the adherent cells of the primary tumor.The study is published in the current issue of the journal Molecular Cancer Research. However, as researcher Erika Dahl explains, “A hallmark of cancer cells is that their metabolic processes are often different from normal, healthy cells.”  This is called metabolic reprogramming. As one of the outcomes, study author Katherine Aird says, “Cancer cells can grow forever without stimulus.” 70% of HGSC relapse despite treatment, becoming resistant to chemotherapy, which makes the new discovery a true potential breakthrough in the treatment of this tumor.All life at cellular and organism level depends upon thousands of life processes that provide and degrade a range of chemicals required for proper function of the cells and tissues. These intricately interdependent processes together they make up the body’s metabolism. Cancer cell Illustration. Image Credit: Jovan Vitanovski / Shutterstocklast_img read more

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Feds Powell affirms rate cut view others see US economy humming

first_img {{category}} {{time}} {{title}} ATLANTA/VICTOR, Idaho: As Federal Reserve Chair Jerome Powell kept the focus Thursday on global risks that could trigger a Fed rate cut in coming weeks, his colleagues from regional Fed districts painted a rosier picture of continued U.S. economic growth and a solid business outlook.The contrasting remarks show the dilemma the Fed faces as it heads towards an end-of-month monetary policy meeting now broadly expected to end with a rate reduction.On one hand – emphasised by Powell in Congressional hearings Wednesday and Thursday and seconded by the influential chief of the New York Fed and Fed Governor Lael Brainard — global trade and economic risks have put a dent in investment, inflation is well below the Fed’s 2% target, and the U.S. expansion may need a shot in the arm.But as they polled businesses in their districts, Atlanta Federal Reserve Bank President Raphael Bostic and Richmond Federal Reserve Bank President Thomas Barkin saw an economy still humming, and no clear need for the Fed to ease monetary policy. Powell has pointed to a number of national surveys as evidence business confidence took a hit recently. Economy 11 Jul 2019 Fed’s Powell signals rate cut as trade war outweighs strong job market Economy Related News Related News Business News 09 Jul 2019 Fed easing likely to prompt China rate cut Tags / Keywords: “I am not seeing the storm clouds actually generate a storm yet,” said Bostic, who described himself as skeptical of the need to cut interest rates right now. “With very few exceptions businesses are telling me the economy is performing as strong as it was. They are not seeing weaknesses in consumer engagement. And they are not materially changing their plans.””I’ve been out in the last couple weeks and I’m talking to business people,” Barkin said on Thursday. “They are not yet leaning back…They are not cutting jobs, They are not cutting investments that have already been underway. But they are cautious…They haven’t stopped, they’ve just slowed.”More detail about on-the-ground business sentiment may come next week when the Fed releases its latest Beige Book compendium of anecdotal information from the 12 Fed districts.Powell has pointed to a number of national surveys as evidence business confidence took a hit recently, particularly in May after President Donald Trump threatened to impose tariffs on Mexican imports unless his demands about tougher immigration enforcement were met.The tariffs were not levied, but “it was a bit of a confidence shock, Powell told the Senate Banking Committee.In Albany, New York Thursday, New York Fed President John Williams, added his voice in support of a rate cut, citing uncertainties around trade and global growth and soft inflation. “The arguments, for adding policy accommodation have strengthened over time.”Brainard, in a separate appearance in Scranton, Pennsylvania, piled on. “Taking into account the downside risks at a time when inflation is on the soft side would argue for softening the expected path of monetary policy according to basic principles of risk management,” she told a community banking group.Neither Barkin nor Bostic have a vote this year on the Fed’s rate-setting committee. But they will participate in the debate when the Fed meets in three weeks in a session widely expected to reduce the Fed’s overnight target interest rate by at least a quarter of a percentage point.Investors expect that cut with near 100% certainty.Powell, in appearances on Capitol Hill this week, bolstered expectations such a cut is coming, and focused on the need to protect the United States against fallout from a weak global economy.Neither Barkin nor Bostic ruled out supporting a rate cut, which, according to minutes of the Fed’s June meeting, has drawn support for a variety of different reasons — both the global tensions Powell has focused upon, as well as weak inflation and a sense that the Fed had unintentionally set policy too tight with its four interest rate increases last year.At least a couple regional Fed bank presidents do support a rate cut, including St. Louis Fed Bank President James Bullard, and Minneapolis Fed President Neel Kashkari who on Thursday said he is advocating the “stronger medicine” of a half-percent rate cut. Both men say a rate cut is needed to boost inflation expectations.But other regional bank presidents have in recent days said they were struggling to justify lower rates at a time when unemployment is near a historic low, at 3.7%, and job growth continues apace.Bostic said that even recent weak inflation data may not be as worrisome as it might seem.With the Fed’s current preferred measure of inflation running at 1.6%, below the 2% target, some policymakers argue the central bank needs to do more or risk losing public trust that it takes the target seriously.”If the public comes to believe that a persistent downside miss to the 2% goal means the FOMC is not committed to that goal, then there is a problem,” Bostic said.But he added that his analysis of inflation expectations, based on surveys of professional forecasters and business executives, left him unconvinced that expectations are slipping. In addition, less “noisy” measures of actual inflation, which strip out the most volatile terms, indicate “that right now we are very close to our 2% price stability mandate.” – Reuters Markets 11 Jul 2019 Asia stocks rise, dollar sags as Fed chair sets stage for rate cutlast_img read more

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Classy Djokovic charges into another Wimbledon final

first_imgLONDON (Reuters) – Top seed and defending champion Novak Djokovic held off a spirited challenge from Spanish outsider Roberto Bautista Agut on Friday to triumph in four sets and advance to a mouthwatering Wimbledon final against Roger Federer.Remarkably the Serb’s 6-2 4-6 6-3 6-2 success was the 12th victory in his last 13 Grand Slam semi-finals and he is now one win away from his fifth title at Wimbledon and 16th Grand Slam singles crown as he resumes his great rivalry with the Swiss.Friday’s match turned on an amazing 45-shot rally in the seventh game of the third set, which Djokovic won to hold serve and stay a break up – and from then on he took total control as the Spaniard, who had looked calm and confident in his first Grand Slam semi-final, was eventually brushed aside.”I had to dig deep. It’s the semi-finals and Roberto was not overwhelmed – he’s a very under-rated player,” Djokovic, 32, said. Tennis 10 Jul 2019 Ibiza party on hold as Bautista Agut reaches Wimbledon semis Related News Tennis 10 Jul 2019 Highlights: Wimbledon day nine “He played really well. He was managing his nerves in the first set but later on he established himself and started to play better. I got a bit tight. It was a close opening four or five games of the third set – that’s where the match could have gone a different way.”Bautista Agut flashed a brilliant return past Djokovic from the first serve of the match but he barely threatened for the rest of the set as his high-risk approach produced too many errors and a provided a straightforward set win for the favourite.The second was a different story as Bautista Agut dialled back a little and found that he was able to out-duel the master. Djokovic was making uncharacteristic errors on seemingly simple shots and was frequently left staring skywards, questioning himself and taking issue with the crowd.Bautista Agut snatched a break in the third game and served superbly to back it up, dropping only four points in five successful service games to level the match.REAL MATCHThe Centre Court crowd realised they had a real match on their hands and they were treated to a superb third set. It, and probably the match, hinged on the seventh game as Djokovic, a break to the good, served at 30-40.The players then smashed out their 45-shot rally, much of it a mesmerizing exchange of identical crosscourt backhands that had the crowd gasping before Djokovic blinked first to switch the angle of attack and take the point with a devastating winner.It was the longest rally officially seen at Wimbledon since records began in 2005 and Djokovic duly served out and stayed on top to take the set.The champion then took command in the fourth set, cutting out the loose groundstrokes and picking up points with adventurous serve-and-volley attacks and after breaking for a 2-1 lead he never looked back.”Obviously winning that game was crucial for me,” Djokovic said of the marathon rally game. “It gave me more confidence and relief so I could swing more freely in the next games.”Bautista Agut had no answers but can be pleased with his efforts in what is turning out to be the best year of his career, having never previously reached even a quarter-final at a Grand Slam.The 31-year-old can now join his friends on a belated stag break. They arrived in London to watch Friday’s game after his planned Ibiza trip was cancelled following his unexpected progress to the last four.Djokovic, however, has got more business to attend to as he prepares to face 37-year-old eight-times Wimbledon champion and number two seed Federer in Sunday’s showpiece.”Regardless of the history and many finals I’ve played, playing a final at Wimbledon is something different so I’ll definitely enjoy that experience,” he said. (Reporting by Mitch Phillips, editing by Ken Ferris)center_img Tennis 10 Jul 2019 Clinical Djokovic destroys Goffin to reach semis {{category}} {{time}} {{title}} Related Newslast_img read more

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